Cold and chills may be a pre-febrile reaction to chills. Depending on the situation, general treatment or symptomatic treatment with antipyretic drugs such as acetaminophen and ibuprofen may be indicated. Colds are mostly caused by viral infections and are self-limiting, usually resolving in 5-7 days. If the symptoms are mild, there is no need for medication, but only general treatment, such as drinking plenty of fluids, eating a light diet, and taking care of rest. If the symptoms are serious, symptomatic treatment can be given. If the fever exceeds 38.5℃, acetaminophen, ibuprofen and other drugs can be given. Acetaminophen is often used to treat fever caused by the common cold. It is contraindicated for those who are allergic to the product and those with severe hepatic or renal insufficiency. Adverse reactions such as rash, hives, drug fever and granulocytopenia are occasionally seen after use. Ibuprofen can be used for fever caused by the common cold or influenza. It is contraindicated in people who are allergic to this drug, pregnant and lactating women, asthmatics who are allergic to aspirin, people with severe hepatic or renal insufficiency, people with a history of peptic ulcer, gastrointestinal bleeding or perforation. The main adverse reactions are nausea, vomiting, rash and so on. If the body temperature is high, persistent or aggravated after a cold, you should seek medical advice and treatment under the guidance of a doctor, do not take medication without authorization, so as not to delay the condition.