The patient, Ms. Gan, was hospitalized with unexplained jaundice, and was admitted with a jaundice index of more than 200 and transaminases of more than 1400 u/l. After MRI and various related examinations, no abnormalities such as biliary obstruction or hepatitis were found. Further questioning of the medical history revealed that the patient had taken oral medication for half a year before the onset of the disease due to gray nails, resulting in drug-related liver damage. After a long period of symptomatic treatment such as liver protection and enzyme lowering, the patient recovered to normal. The liver is the body’s largest detoxification organ, almost all drugs have to go through the liver metabolism, all have different degrees of toxicity to the liver, especially anti-mycotic and other drugs, long-term use of more damage. To avoid drug-related liver injury, you should do the following: 1, under the guidance of a doctor to take drugs, do not take drugs indiscriminately, 2, as far as possible, choose drugs with less liver toxicity, if necessary, you can take liver protection drugs at the same time, 3, the need for long-term use of drugs, be sure to regularly review liver function, found abnormalities, early discontinuation of drugs and treatment. After treating a patient with drug-related liver injury, I wrote this article because of the people’s blind reliance on drugs and the prevalence of drug abuse, which was first published in the Wuhan Morning Post and is now posted online, hoping it will be helpful.