Disulfiram itself is a drug for alcohol withdrawal. Disulfiram inhibits acetaldehyde dehydrogenase in the liver when used in combination with ethanol, so that after the oxidation of ethanol to acetaldehyde in the body, it cannot continue to break down and oxidize, resulting in a series of reactions due to the accumulation of acetaldehyde in the body. The onset of disulfiram-like reactions is rapid, and symptoms generally occur within a few minutes to 2 hours of drinking alcohol, and the period from onset to remission is its risk period. Drinking alcohol after taking drugs containing methyl tetrathionazole structure such as cefoperazone, cefoperazone sulbactam, ceftriaxone, cefazolin, cefradil, cefmetazole, cefminoxime, cefamandole, cefalexime, cefamandole, cefalexin, cefaclor, dysentery, chloramphenicol, furantoin, metronidazole, etc., can lead to the accumulation of acetaldehyde in the body and produce toxic reactions. The main manifestations are chest tightness, shortness of breath, laryngeal edema, blue lips, dyspnea, increased heart rate, decreased blood pressure, hallucinations, trance, and even anaphylactic shock. The severity of disulfiram-like reactions is directly proportional to the dose of applied drugs and the amount of alcohol consumed. For patients with mild symptoms, they usually do not need special treatment and can recover on their own. However, in case of severe reactions, such as respiratory depression, deficiency, convulsions and cardiac dysfunction, the patient should go to the hospital emergency or internal medicine department to take appropriate rescue measures, such as gastric lavage, intravenous infusion of dexamethasone, improving circulation, promoting drug metabolism by reducing glutathione and raising blood pressure, etc. Usually, after active treatment, most patients can gradually remit within 12 hours. Therefore, alcohol consumption is usually not recommended while taking medications for treatment.