Right lobe hypodense nodule is an imaging term that refers to nodular shadows found in the parenchyma of the right lobe of the liver that are lower than the normal density of the liver parenchyma, which is mostly suggestive of the presence of benign tumors such as hepatic hemangiomas or malignant tumors of the liver. A normal liver tends to appear as a homogeneous isodensity on imaging. When low-density nodules are scanned in the right lobe of the liver, the possibility of hepatic hemangioma, hepatic malignancy, and focal nodular hyperplasia of the liver are usually considered. 1. Hepatic hemangioma. Imaging usually shows a well-defined round or roundish low-density mass visible in the liver. 2. Hepatic malignant tumor. Generally, it can be presented as a hyperechoic nodular lesion with unclear border and irregular morphology. 3. Focal nodular hyperplasia of the liver: CT scan can present as slightly hypodense nodular shadow. There are many reasons that lead to the appearance of low-density nodules in the liver, and it is recommended that the patient seek regular medical treatment in a timely manner.