Myeloid leukemia is known as acute myeloid leukemia. A missense mutation in the sh2b3 gene is when the amino acid codon encoding the sh2b3 gene is changed to another amino acid codon after a base substitution. The result of a missense mutation in the sh2b3 gene generally results in the loss of the original function of the polypeptide chain, which leads to abnormal synthesis of many proteins. The causative factors in patients with acute myeloid leukemia may include missense mutations in the sh2b3 gene. However, acute myeloid leukemia sh2b3 gene missense mutation is complex, and the relationship with blood diseases is not completely clear. If, after formal genetic testing, an acute myeloid leukemia sh2b3 gene missense mutation is found, appropriate therapeutic measures should be formulated under the guidance of a doctor and formal treatment should be carried out in a timely manner. Medications include cytarabine and Zoerythromycin.