The correlation between psoriasis and hyperuricemia has been recognized by many scholars, and Eisen and Seegmiller measured serum uric acid levels in 38 patients with common psoriasis and showed that 25% of patients had hyperuricemia . Beveridge and Lawson tested serum uric acid levels in 31 patients with non-common psoriasis and showed that 36% of patients had hyperuricemia blood. The serum uric acid level of 70 patients with psoriasis vulgaris was measured by sodium hydride – urea method and 47.14% had hyperuricemia. Shi Shouyi et al. tested serum uric acid in 80 patients with common psoriasis and 55 patients with non-common psoriasis, and 80 normal subjects were used as controls, and the results showed that serum uric acid levels were elevated in 30% of patients with common psoriasis and 67.27% of patients with non-common psoriasis. However, the relationship between psoriasis and serum uric acid levels has been poorly reported in the literature in recent years. The results of this paper showed that serum uric acid values were significantly higher in the group of patients with non-common psoriasis than in the group of patients with common psoriasis and even higher than in the normal group. The most striking histopathological features of psoriatic lesions are epidermal hyperkeratosis and hyperkeratosis. Increased epidermal cell proliferation and conversion rate accelerates the catabolism of purine nucleotides, which are converted to purine by the catalytic action of nucleotidases and nucleotide phosphorylases, and then hydrolyzed, deaminated, and oxidized to produce uric acid. Lundquist et al. found that xanthine gin oxidase and urinary gin enzymes, which play a decisive role in nucleotide metabolism, have increased activity in the psoriatic epidermis, and concluded that the increased serum uric acid in psoriasis is the result of an increased rate of nucleic acid degradation in the lesions. Memory-effect T cells from patients with psoriasis enter the circulation and migrate to the skin, where T lymphocytes secrete inflammatory cytokines that promote keratin-forming cell production, thereby initiating an immune-mediated inflammatory cascade response, along with increased expression of adhesion factors in vascular endothelial cells that attract large numbers of inflammatory cells to accumulate in the lesions. The large number of inflammatory cells that accumulate at the lesions may further promote epidermal cell proliferation, which in turn undergoes a series of biochemical reactions to produce uric acid. It has been reported in the literature that one author measured urinary excretion of 4C uric acid in psoriasis patients using 14C-labeled glycine and found that it peaked on day 8, which is consistent with the epidermal transition cycle. Moreover, uric acid excretion was normal after treatment. Tan Zhongkai suggested that the cause of hyperuricemia in psoriasis patients may not be unique, perhaps there is a genetic link to psoriasis and an association with nutritional factors, but we disagree with the study that psoriasis is not associated with hyperuricemia, probably because the authors included minors in the study (minors usually have lower serum uric acid). Regarding the relationship between serum uric acid levels and age, from this paper, patients were compared into 3 age groups (all adults), and the difference in elevation rates was not statistically significant. Feng Lei et al. concluded that the difference between serum uric acid in adults and children was large, while the difference between adults was not significant. The subjects selected for this paper were all adults over 20 years of age. Shi Shouyi also concluded that the difference in blood uric acid levels among adults was not significant. The difference between male and female sexes has been agreed by most scholars, and the results of the author’s experiment are consistent with this. Eisen and Seegmiller suggested that the greater the extent of skin lesions, the higher the rate of uric acid elevation. Zhao Qingli et al. suggested that the specific damage of psoriasis is an important factor affecting the elevated blood uric acid level. Our experiment found that although the serum uric acid values of psoriasis patients were significantly higher than those of the control group, there were no significant changes in the serum uric acid values of the various stages of common psoriasis, and there was little correlation between the decrease or increase in PASI scores and the serum uric acid values of psoriasis patients. All these conclusions await our further studies in the future. Is psoriasis associated with visceral disease? Domestic scholars such as Chang et al12 believe that psoriasis associated with or secondary to disease is an independent disease and its occurrence is not related to psoriasis. Some scholars who agree with this view believe that psoriasis patients have accelerated proliferation of keratin-forming cells in the basal layer of the epidermis and metabolic disorders.13 Thus, we further speculate that hyperuricemia in psoriasis patients may be caused by psoriasis itself. Therefore, I believe that it is essential to test serum uric acid levels in patients with psoriasis because hyperuricemia increases the risk of cardiovascular disease in addition to gout and renal impairment.