Fatigue is a common symptom in cancer patients, and some studies have shown that >70% of patients will have fatigue. Cancer-related fatigue (CRF), also known as cancer fatigue, is a subjective feeling caused by the tumor itself or its treatment, with fatigue as the main manifestation. It can be caused by the cancer itself or related to anti-tumor treatment. In patients receiving chemotherapy, fatigue can peak within a few days of chemotherapy, and then tends to decrease until the next cycle of chemotherapy. In patients receiving radiation therapy, fatigue is cumulative and its severity may peak after a few weeks of radiation therapy. Other factors causing fatigue, such as tumor associated anemia, depression, etc. The complex etiology of tumor-associated fatigue determines that doctors should develop specific and individualized treatment plans when dealing with fatigue based on the full evaluation of the degree of fatigue and influencing factors, and constantly adjust them according to the development of the disease. Treatment methods Controlling tumor-related fatigue requires the joint efforts of patients and medical personnel, and the treatment means can be roughly divided into two categories: non-pharmacological treatment and pharmacological treatment: 1. Non-pharmacological treatment mainly targets patients with mild fatigue. (1) Reasonable arrangement of life Tumor patients should develop a regular work and rest system, switch to easy and suitable work, and ensure sufficient sleep to reduce unnecessary energy consumption and preserve energy and strength. (2) Psychosocial intervention ①Education and information intervention: Many cancer patients are not psychologically prepared for the fatigue caused by anti-cancer treatment. At this time, some relevant education should be provided to patients so that they can have a certain understanding of the disease and the problems arising from the treatment and master the coping methods, which is no less effective than some specific treatments. (2) Psychological and behavioral therapy: Psychological therapy including psychological counseling, relaxation training and forming mutual support groups with sufficient time can improve patients’ mental state and relieve cancer-caused fatigue, which is an area that should be paid attention to in the treatment of cancer-caused fatigue. (3) Nutritional support Tumor patients simply increasing food intake cannot improve cachexia, but by maintaining good nutritional status, it is beneficial to relieve fatigue. It is currently advocated to give high protein diet to oncology patients and emphasize a reasonable dietary structure. In addition, supplementation with unsaturated fatty acids such as fish oil, especially purified eicosapentaenoic acid can reduce muscle and fat consumption, promote anabolism, weight gain, and reverse the cachexia state. At the same time, unsaturated fatty acids can also regulate the synthesis and release of cytokines and affect the cellular immune status of patients. (4) Physical exercise Most tumor patients and doctors believe that patients should not be too nervous during radiotherapy and chemotherapy, and should rest more, but theoretically excessive braking will lead to disuse hypofunction and aggravate fatigue. Exercise, even during active treatment, has improved physical fitness, endurance, hematocrit levels and quality of life for cancer patients, with reduced fatigue and antidepressant effects. Currently, the recommended exercise regimen focuses on aerobic endurance training such as pedaling and slow walking. Such exercises can improve cardiac function and increase the supply and utilization of oxygen to muscle tissue. Physical exercise can also reduce the muscle consumption of tumor patients and decrease the fat content of the body. (5) Other: some rehabilitation treatments are also recommended. 2.Pharmacological treatment mainly targets patients with moderate fatigue or above. (1) For tumor-related fatigue, firstly, the cause and degree of fatigue should be assessed and targeted treatment should be carried out. For example, treatment of depression and anxiety, improvement of anemia and cachexia, correction of endocrine disorders and sleep disorders. At present, there is no special treatment drug. Some studies have reported that the application of corticosteroids and central excitatory drugs can relieve fatigue, but further research is still needed. (2) Treatment of affective disorders: If the patient has a certain degree of anxiety and depression according to the diagnosis, the corresponding anti-anxiety and depression treatment drugs can be used. Some antidepressants have been reported to reduce fatigue, hot flashes, insomnia and night sweats in breast cancer patients. Glutamine was previously used for hepatic encephalopathy and some mental system diseases. Currently, some studies have shown that glutamine supplementation for tumor patients can not only improve psychological status, but also improve activity endurance. (3) Correction of anemia: The improvement of anemia can obviously improve the quality of life and functional status of patients, correct the hypoxic state of tumor tissues and increase the sensitivity of chemotherapy. (1) Blood transfusion: Fatigue is one of the common symptoms of tumor patients requiring blood transfusion, but due to the possibility of spreading disease, affecting immune function and increasing treatment cost, blood transfusion is currently mostly used only for anemic patients in acute and severe cases. ②Erythropoietin: Erythropoietin synthesis is relatively or absolutely reduced in tumor patients, which provides a theoretical basis for the clinical application of these drugs in the treatment of tumor-associated anemia. The use of EPO (Ebio): 150-200 IU/(kg/time), subcutaneous injection, 3 times/week. (3) Supplementation of iron, folic acid and vitamin B12 as appropriate. (4) Treatment of cachexia: analyze the main factors for the occurrence of cachexia in patients and apply some treatments in addition to nutritional support and physical exercise.