With the shift of biological, psychological and social medicine model, more and more scientists believe that malignant tumor is also a psychosomatic disease. With the change of biopsychosocial medical model, more and more scientists believe that malignant tumor is also a psychosomatic disease, and the adverse emotion caused by the stressful stimulation of psychosocial factors is often an important factor in causing malignant tumor. The adverse psychological factors as a psychological aid to treatment of stressful stimuli are often important factors in causing malignant tumors. With the change of biological, psychological and social medical model, more and more scientists believe that malignant tumor is also a psychosomatic disease, and the bad emotion caused by the stressful stimulation caused by psychosocial factors is often an important factor to cause malignant tumor. On the one hand, adverse psychological factors as stressful stimuli can affect hormone secretion and cause the body’s immune system to be suppressed by the abnormal internal environment, and the ability to resist diseases, especially malignant tumors, decreases; on the other hand, it increases the possibility of various carcinogenic factors acting on human body, which will eventually lead to the occurrence of cancer. Quality of life is defined as the degree of satisfaction of a person with life. It is influenced by individual background factors, health-related factors and social, cultural and environmental factors. Quality of life consists of four basic elements, namely life satisfaction, self-concept, health and functioning, and socioeconomic factors: According to the survey, 58. 75% of cancer patients have psychological disorders, which seriously affect the progression of treatment and care. The implementation of psychological care for malignant tumor patients can change the patients’ attitude towards disease awareness and improve the quality of life of patients and even the whole family. Some of the symptoms of advanced malignant tumors can be relieved by drugs, but they must be accompanied by more and more detailed clinical care to alleviate various discomforts and pains of patients. Psychotherapy is irreplaceable in malignant tumors. Changes in psychological state will affect human autonomic system, all levels of brain organization and endocrine system activities. Psychotherapy is a kind of self-regulation, which can regulate the psychological state of people and put them in a good state, so as to mobilize various biological factors to work together to produce a good internal environment, increase the level of cellular immunity to a certain extent and enhance the anti-tumor ability of human body, so as to achieve the effect of effectively inhibiting tumor cells or even killing them. According to traditional theory, the hypothalamus, pituitary and adrenal axis are responsible for the development of tumor cells. Pituitary-adrenal axis (HPA) is the mechanism of stress-induced immunosuppressive effect. Stressful stimuli cause the adrenal cortex to secrete steroids through the hypothalamus, which can reduce macrophage viability, interfere with the recirculation of lymphocytes, cause lymphatic tissue degeneration and alter the influence of lymph nodes on the occurrence and development of immune responses. It also degrades the thymus gland and prevents the maturation of T lymphocytes, which decreases the cellular immune function of human body. Also corticosteroids can inhibit the formation of immunoglobulins, thus affecting the humoral immune function, which will cause the human body’s resistance to decline and cause disease. Fawzy et al. concluded that rational psychological care treatment can improve the immunity of patients to a certain extent by improving the function of human stress system and immune system. Psychotherapy works precisely by improving the psychological state, which in turn improves the psychological state of prostate cancer patients and increases their survival time.