Pain in the big toe can be caused by nail infection or gout nodules. If the pain is caused by nail fungus, it is manifested on the outside or inside of the toenail, mostly due to soft tissue infection caused by the toenail growing into the flesh during trimming, which is manifested by redness, swelling, pain and even pus on both sides of the toenail. If necessary, oral antibiotic treatment, such as cefixime or cefradine can be taken. If an abscess forms with local fluctuation, the abscess needs to be cut open to drain the wound for a change of medication, and if necessary, the stent will be removed and the wound changed. Gout nodules cause pain at the root of the toe, red gout nodules can be found, the surface pain is obvious, it is caused by the increase of uric acid, need to take oral allopurinol symptomatic treatment. During the treatment process, it is not possible to drink beer, eat seafood, animal offal and other foods.