Glibenclamide belongs to the sulfonylurea class of glucose-lowering drugs and is an oral hypoglycemic agent commonly used in clinical practice. Glibenclamide works by promoting insulin secretion, so it is only suitable for type 2 diabetes, not for type 1 diabetes. The common side effects of glibenclamide include the following: 1. Hypoglycemia, glibenclamide works by stimulating insulin secretion, so hypoglycemia is likely to occur when the patient eats irregularly or the drug dose is too large. The metabolites of glibenclamide also have hypoglycemic effects, and severe and persistent hypoglycemia, even hypoglycemic coma, may occur, especially in middle-aged and elderly patients. 2. weight gain, insulin can lead to weight gain, and glibenclamide works by promoting insulin secretion, and the side effect of weight gain may also occur. 3. drug allergy, a few patients may experience itchy skin and rash after taking it. 4, Gastrointestinal reactions, a few patients may experience upper abdominal discomfort and nausea after taking it. 5. Hematological reactions, some patients may experience leukopenia after taking glibenclamide. 6. Liver and kidney damage, glibenclamide may aggravate liver and kidney damage, so use with caution in patients with liver and kidney insufficiency.