Eating a cephalosporin and drinking one or two white wine should be observed for at least 48 hours to be considered okay. After eating cephalosporin, you can not drink white wine, cephalosporin and alcohol will occur disulfiram reaction, facial flushing, tachycardia, chest tightness, fatigue, headache, dizziness, abdominal pain and other discomforts, the serious cause shock, or even death, eat cephalosporin drank one or two white wine at least 48 hours of observation before it is considered all right, and at the same time, drink more water to promote the metabolism of alcohol. During the period of taking cephalosporin, must avoid drinking alcohol, usually 7 days after stopping the drug can drink alcohol, in order to avoid disulfiram-like reaction. The reason is that cephalosporin antibiotics inhibit the enzyme acetaldehyde dehydrogenase, resulting in high concentrations of acetaldehyde, and if the drug is discontinued, acetaldehyde dehydrogenase takes 4 to 5 days to return to normal. Occurrence of disulfiram-like reaction, should be timely hospital consultation, under the guidance of physicians to deal with, it is recommended that if the chest tightness, fatigue, headache, dizziness and other uncomfortable symptoms, as soon as possible to avoid delay in the condition.