How old can you live with methylmalonic acidemia?

Patients with methylmalonic acidemia generally do not live very long, some may live into their 30s, but it depends on the individual patient and treatment. Methylmalonic acidemia is a chromosomal recessive disorder with an early onset, manifesting as stunted growth at age 4, recurrent episodes of vomiting, dehydration, hypotonia, and in some patients, mental retardation, hypoglycemia, and in severe cases, ketoacidosis. Some idiopathic cases may present with neuromuscular lesions, behavioral abnormalities, and hematologic abnormalities. Enlarged liver may be detected by ultrasound, abnormal brain waves on EEG, and backward intellectual level. The main treatment for this disease is dietary therapy with early initiation of protein restriction and the need for oral medications for symptomatic management, which are administered according to medical advice.