For thyroid nodules with malignant signs, it is necessary to perform a puncture biopsy to determine the benign or malignant nature of the nodule. Thyroid puncture biopsy can be performed on thyroid nodules of unknown nature or suspected malignancy if one of the following symptoms is present: ultrasound suggestive of malignant nodules; accompanied by ultrasound abnormalities of cervical lymph nodes; history of cervical irradiation in childhood; family history of thyroid cancer or history of thyroid cancer syndrome; ¹⁸F-FDG PET/CT positive imaging; accompanied by abnormally elevated serum calcitonin levels. abnormally elevated serum calcitonin levels. It is recommended that patients with thyroid nodules go to regular hospitals in time to improve the relevant examinations and standardized treatment under the guidance of doctors to avoid delaying the condition.