Hand numbness after waking up in the morning need to be alert to more diseases, not necessarily five, mainly including cerebrovascular disease, cervical spondylosis, carpal tunnel syndrome, peripheral neuritis, rheumatoid arthritis and so on. If the patient wakes up in the morning after a sudden, persistent numbness of one side of the limbs, need to be alert to cerebrovascular disease, need to further check the cranial CT or nuclear magnetic clear diagnosis. If the patient is paroxysmal hand numbness, accompanied by neck discomfort, need to exclude cervical spondylosis. Carpal tunnel syndrome is mainly due to the compression of the median nerve causing numbness in the palm side of the finger, thumb and middle finger. The main symptom of peripheral neuritis is that the patient will have bilateral symmetrical glove-like sensory impairment at the end of the limbs. Rheumatoid arthritis also occurs in some patients with hand numbness discomfort, which can be accompanied by morning stiffness, and the symptoms can be relieved after activities. There are many diseases that cause morning numbness and swelling of the hands, and it is recommended to consult a doctor in time and differential diagnosis, and treatment for the cause of the disease.