Lung nodular vacuoles are benign lesions that need to be recognized in the context of the clinical history. Common benign lesions include inflammation, tuberculosis, and nodular disease. 1. Inflammation: Some cases of aspiration pneumonia or specific bacterial infections are associated with liquefaction and necrosis in the center of the lesion. 2. Tuberculosis: tuberculosis forms caseous granulation tissue, and after the center liquefies and necrotic, there will be corresponding changes along the bronchial drainage. 3. Nodular disease: it is related to various pathogenic infections and abnormalities of immune factors, and it is non-caseous granulation tissue, which will have corresponding changes after liquefaction and necrosis. Lung nodules accompanied by vacuolar signs, may also be malignant signs, need to go to the regular hospital in a timely manner, through the examination of the diagnosis of the cause of the disease, under the guidance of the clinician to standardize the treatment, to avoid delays in the condition.