Waking up in the middle of the night with itchy ears may be caused by eczema of the ear canal, fungal infection and other reasons. 1. Eczema of the external auditory canal: Eczema of the external auditory canal is caused by contact with irritants or allergic substances in the external auditory canal, which leads to red spots, pimples, flaking and itching on the local skin of the external auditory canal or auricle. Sleeping at night at a higher temperature may aggravate the symptoms of itching, so the ear wakes up in the middle of the night with itching. 2. Fungal infection: due to environmental humidity and other reasons lead to the ear canal is infected by pathogenic bacteria, the patient appeared in the external auditory canal fungal growth, the formation of clumps, itching, ear stuffy blockage and other symptoms, when sleeping on the side at night, will be due to the external auditory canal environment is more humid, ventilation is poor, itchy lead to itchy wake up. Wake up in the middle of the night ear itching may also be caused by other reasons, it is recommended to go to the hospital in a timely manner, to clarify the cause of the disease, and then follow the doctor’s instructions for treatment.