Anal pain can be seen in perianal abscess, anal fissure, hemorrhoids and other diseases, according to the different diseases, treatment with anti-inflammatory drugs are not the same, should be used after diagnosis by a professional doctor. Perianal abscess is often due to anal gland obstruction infection caused by purulent infectious diseases of perianal tissues, manifested as anal pain, redness, swelling, fever, treatment of anti-inflammatory drugs are mainly oral or static antibiotic-based, such as ceftriaxone, amoxicillin, levofloxacin and other anti-infective treatment. Anal fissure is mainly related to dry stool, manifested as severe pain in the perianal area, the pain can be radiated to the surrounding area, accompanied by blood in the stool, perianal itching and so on. Drug treatment mainly has laxatives and painkillers, such as lactulose, ibuprofen, etc., anti-inflammatory drugs can not be used, such as anal fissure ulcers combined with infection, can be given locally to the erythromycin ointment, lincomycin ointment, etc., if necessary, standardized use of medication under the guidance of a doctor. Hemorrhoids is the anal canal and rectal end of the submucosal blood vessels varicose blood stagnation caused by venous masses, when hemorrhoids congestion and edema caused by perianal pain, if secondary infection occurs can follow the doctor’s instructions oral anti-inflammatory drugs, such as erythromycin, cefuroxime. Patients with anal pain, it is recommended to go to the hospital in a timely manner, clear the cause of the disease, follow the doctor’s instructions to give treatment, do not blindly use their own medicine, so as not to cause adverse effects.