Cytomegalovirus (CMV) is a common group of opportunistic infections that occur in immunocompromised patients with AIDS, malignant hematologic tumors, and organ or hematopoietic stem cell transplant patients. Children and adolescents are latently infected, and most patients develop symptoms after several years. Cytomegalovirus infection has a variety of clinical symptoms, including pneumonia, encephalitis, hepatitis, gastrointestinal ulcers, retinitis, and eventually disseminated disease, while skin involvement is rare, with symptoms such as maculopapular rash, scarlet-like lesions, urticaria, skin and oral ulcers, and nodular or warty lesions. Skin lesions are the first symptoms of cytomegalovirus disseminated infection and have a high disability and mortality rate. Histopathological examination commonly reveals enlarged capillary endothelial cells with inclusion bodies in the nucleus and cytoplasm, a “hawk’s eye” sign, and perivascular inflammatory cell infiltration. Cytomegalovirus immunological staining is specific and does not cross-react with other herpesvirus antigens. In conclusion, cytomegalovirus infection is a class of opportunistic infections that are most often seen in immunocompromised patients. Cutaneous symptoms are rare and often predict systemic disseminated infection with a poor clinical prognosis.