Polycystic kidney can be punctured twice. Polycystic kidneys need to be punctured for larger cysts to reduce the pressure of cysts on the kidneys, slow down the deterioration of the condition, and reduce the damage of cysts on renal function and the pressure on the renal parenchyma. Therefore, according to the specific condition of polycystic kidney, second puncture or even multiple punctures can be performed to relieve the symptoms. Polycystic kidney is a common hereditary kidney disease, the main feature is the presence of multiple cysts in the kidneys, once these cysts appear progressive growth, it will lead to the compression of renal structure and function, resulting in end-stage renal failure, and generally can be relieved through the treatment of puncture surgery. In addition, polycystic kidney has a certain degree of danger, patients need to regular hospitals, under the guidance of specialists to actively seek treatment.