How to treat white matter degeneration mainly depends on the cause of white matter degeneration and the severity of the degeneration, as follows: 1. No treatment is needed: if the patient’s white matter degeneration is relatively mild and does not cause obvious neurological deficits, this kind of patient doesn’t need to be treated, and only needs to undergo regular imaging examinations such as CT, MRI, etc. 2. Symptomatic treatment: if the white matter degeneration is very serious, resulting in dementia and other serious neurological deficits, this kind of patient needs to be actively treated. If the degree of white matter degeneration is very serious, leading to dementia and other serious symptoms of neurological deficits, this kind of patients need active treatment. The causes of white matter degeneration mainly include arteriosclerosis, viral infection, autoimmune reaction, etc. Therefore, it is necessary to treat these causes. The most common cause is arteriosclerosis, and the patients need to take anti-arteriosclerosis medicines such as aspirin, clopidogrel hydrogensulfate tablets, and reseruvastatin for treatment. At the same time, dementia and other complications should be treated, and the main drugs for dementia include donepezil, memantine hydrochloride and so on.