If the progesterone shot does not raise the progesterone level, it may be due to abnormal embryo development, and further examination should be done to clarify the reason for the progesterone level not rising. Under normal circumstances, as the weeks of pregnancy increase, progesterone will gradually rise to prevent the mother’s rejection of the embryo, if the progesterone is low, the embryo will be rejected by the mother, thus causing miscarriage. Most of the low progesterone is caused by a woman’s luteal insufficiency, resulting in insufficient progesterone secreted by the corpus luteum. The fact that progesterone does not rise despite progesterone shots is a precursor to miscarriage, indicating that there may be abnormal embryonic development, possibly due to genetic or chromosomal abnormalities in the embryo. When progesterone injections do not increase progesterone, further ultrasound examination is needed to observe whether there are fetal buds, fetal heart, and whether the development of the gestational sac is normal. If the cause is identified, further treatment measures should be taken under the guidance of the doctor.