If the stomach is often difficult in the middle of the night, consider the possibility of duodenal bulb ulcer or duodenal bulbitis is more likely, because the typical symptom of patients with duodenal ulcer is fasting pain, the stomach is in the state of emptying and in the state of fasting in the middle of the night. If this is the case, you can consider doing a gastroscopy to further clarify the diagnosis. In terms of diet, you can take less food and more meals, and it is better to have a snack at night before going to bed, and it is better to eat pasta, which can protect the gastric mucosa. In terms of medicine, you can take omeprazole and bismuth pectin for symptomatic treatment, which is very effective. Patients should adhere to the regular diet and complete the course of treatment according to the regularity, which can be cured.