Subglottic pain can be given according to the etiology with drugs to inhibit gastric acid secretion, drugs to protect the gastric mucosa, analgesic drugs, drugs to increase blood supply to the heart, antibacterial drugs, and chemotherapeutic drugs. It is more common in gastroduodenal disease, esophageal cancer, heart disease, gallbladder disease, trauma and so on. 1. Gastroduodenal diseases: the more common ones are acute and chronic gastritis, gastric ulcer, duodenal ulcer, etc. In the clinic, drugs such as omeprazole, cimetidine and so on can be given to inhibit the secretion of gastric acid, and magnesium alumina carbonate chewable tablets, bismuth pectin and so on can be given to protect the gastric mucosa. 2. Esophageal cancer: Early esophageal cancer can cause pain under the raphe, and those with severe pain can be given pain relieving drugs such as ibuprofen and tramadol, etc. It is advisable to give early surgical treatment, and give relevant drugs and chemotherapy, such as capecitabine, paclitaxel, etc., after the operation. 3. Heart disease: mostly seen in myocardial ischemic disease, such as angina pectoris, myocardial infarction, etc., you can take isosorbide mononitrate and other drugs to expand the coronary arteries, you can also take metoprolol and other drugs to reduce the burden on the heart. 4. gallbladder disease: more common cholecystitis, gallbladder stones, etc., you can take amoxicillin, levofloxacin and other antibacterial drugs, the pain is obvious can also be given scopolamine and other antispasmodic analgesic drugs. 5. Trauma: common for the affected area of the impact injury, pain can be given ibuprofen and other pain medication. There are other causes of subacromial pain, it is recommended to go to the hospital in a timely manner to check the cause of the disease, follow the doctor’s instructions for targeted treatment, the drug has side effects and contraindications, so you need to use under the guidance of a professional physician.