Leflunomide and methotrexate differ in their main effects and indications, contraindications, etc. The specific medication should be chosen according to the patient’s physical condition and specific clinical diseases, and there is no such thing as which one is safer. 1. Leflunomide: it is an immunosuppressant, which can be used for the treatment of autoimmune diseases such as adult rheumatoid arthritis, systemic lupus erythematosus, as well as the anti-rejection reaction of organ transplantation. Adverse reactions such as diarrhea, itching and hair loss can occur with Leflunomide. It is contraindicated in people who are allergic to the product, women in preparation for pregnancy, women during pregnancy, and women during breastfeeding. Use with caution in patients with liver damage, renal insufficiency, immunodeficiency and other diseases. 2. Methotrexate: It is a kind of antifolate antitumor drug and immunosuppressant, the main effect is antitumor, regulating immune function, which can be used in the treatment of various types of acute leukemia, lung cancer and other tumors, psoriasis, rheumatoid arthritis, systemic lupus erythematosus and other immune diseases. Overdose of methotrexate can cause leukopenia, anemia, mucositis and other adverse reactions. It is contraindicated in patients who are allergic to the product, pregnant and lactating women, alcoholic or chronic liver disease. Use with caution in diseases such as hepatic and renal impairment and in children. For Leflunomide and Methotrexate, the specific medication should be chosen according to the patient’s physical condition and specific clinical diseases, and there can be no claim that which one is safer. If you need to take Leflunomide or Methotrexate, you should go to the hospital in time, actively cooperate with the doctor’s treatment plan, and follow the doctor’s instructions, do not blindly take the drug.