The main treatments for toxic diffuse goiter are medication, surgery and iodine-131 treatment. 1. Drug treatment: mainly taking anti-thyroid drugs, such as propylthiouracil or methimazole, which can block the synthesis of thyroid hormone and reduce the level of thyroid hormone. 2. Surgery: If the toxicity of diffuse goiter is more serious, such as obvious enlargement, recurrence after drug treatment, pressure symptoms, or combined with thyroid cancer, etc., it is necessary to consider surgical resection of the thyroid gland, to fundamentally reduce the production of thyroid hormones. 3. Iodine-131 treatment: Iodine-131 is radioactive and can destroy the follicular epithelial cells of the thyroid gland to reduce the secretion of thyroid hormone. In the specific treatment of toxic diffuse goiter, it should be combined with the analysis and diagnosis of professional doctors to choose the appropriate treatment plan.