Venlafaxine and Duloxetine does not exist which effect is better, mainly related to the patient’s degree of tolerance to the drug, as well as the adverse reaction after taking the drug. Venlafaxine and Duloxetine are both new antidepressants, the mechanism of action of the two drugs is similar, so it is difficult to compare the pure therapeutic effect, but the individual’s sensitivity to the drug is different, mainly according to their own situation to choose the efficacy of the drug after the obvious. Venlafaxine adverse reactions are nausea, dry mouth, headache, sweating and so on. When using the drug, note that it is forbidden for those who are allergic to the product and the ingredients contained in it. It should be used with caution in pregnant women, children under 18 years of age, people with hepatic or renal insufficiency, severe heart disease, and patients with high blood pressure. Adverse reactions to Duloxetine include nausea, dry mouth, drowsiness, constipation, loss of appetite. Note that it is contraindicated in people who are allergic to the components of the drug, in patients with untreated narrow-angle glaucoma, and it is forbidden to use it in combination with monoamine oxidase inhibitors. It is recommended that patients use the drug under the guidance of a doctor, and should not use the drug arbitrarily on their own.