The difference between erythromycin gel with isotretinoin and erythromycin is mainly due to the different components and different indications. 1. Different ingredients: isotretinoin erythromycin gel main ingredient isotretinoin and erythromycin; isotretinoin mainly plays the role of inhibiting the growth of keratinocytes, inhibit the role of sebaceous gland differentiation, and there is a certain anti-inflammatory effect; erythromycin is an antibiotic, there is a bacterial killing effect. Erythromycin ointment contains only erythromycin. 2. Different indications: erythromycin ointment indications for ulcer surface infection, impetigo and other suppurative dermatosis, small area burns. And erythromycin isotretinoin gel, in addition to the above effects, can also be used for the treatment of localized unusual acne and pimples. When patients use such drugs, they should pay attention to the adverse reactions such as erythema, swelling, flaking, crusting, etc. When patients experience serious adverse reactions, they should stop the drug and go to the hospital. The above medications need to be used under the supervision of a doctor.