The Gessy procedure is used clinically to treat biliary atresia in neonates, mainly through bile-intestinal anastomosis to relieve biliary symptoms. Since neonates are not compliant compared to children and adults, pacifiers should be used to minimize crying and avoid incisional complications. In addition, because of the possibility of biliary fistulae with biliary anastomosis, the nature of the drainage fluid should be observed after the procedure, and flocculent and cloudy infectious material should be drained. In addition, newborns after Gossy’s procedure should have their liver function and blood counts reviewed regularly for infection and liver function abnormalities. Many newborns may require long-term oral ursodeoxycholic acid and hepatoprotective medications. For immunocompromised newborns, it is important to note that vaccines may need to be temporarily discontinued. Additionally, newborns undergoing the Gossi procedure may also experience further exacerbation of liver lesions and eventually require a liver transplant.