Metformin tablets are best taken by starting with a small dose, gradually increasing the dosage according to the blood glucose indicator, and taking it with meals, which reduces gastrointestinal irritation. Metformin is available in several dosage forms, like regular tablets, enteric-coated tablets and extended-release tablets and extended-release capsules. Extended-release tablets and extended-release capsules are relatively more effective in controlling fasting blood sugar. Regular tablets or enteric-coated tablets are more effective in controlling postprandial blood glucose. Metformin tablets are preferred for use in type 2 diabetes mellitus in which diet and physical exercise alone are ineffective in controlling blood glucose. In order to minimize the occurrence of gastrointestinal complications and in order to use the smallest dose of medication that will allow the patient’s blood glucose to be adequately controlled, metformin tablets should be taken starting with a small dose and gradually increasing the dose. It is usually sufficient to take them with meals, and the dose of the drug needs to be adjusted according to blood glucose indicators. The most common adverse reactions to Metformin Tablets include nausea, vomiting, diarrhea, abdominal pain and loss of appetite. Metformin is contraindicated in patients with severe infections and trauma, severe renal failure or renal insufficiency. Taking metformin, need to follow the doctor’s instructions, blood sugar control is unstable patients, it is recommended to consult a doctor in time, according to the doctor’s instructions to adjust the dosage or change the drug treatment.