Omeprazole and epprazole are different in indications, effects and adverse reactions. 1. Indications: Omeprazole has wider indications and can be used in the treatment of duodenal ulcer, gastrinoma, gastric ulcer, reflux esophagitis, and also can be used intravenously for acute bleeding of peptic ulcer, etc., while epprazole is used in the treatment of duodenal ulcer and reflux esophagitis. 2. Effect: Omeprazole belongs to the first generation of proton pump inhibitors, epprazole belongs to the second generation, epprazole has a faster onset of action, longer half-life, acid suppression effect is also better. 3. Adverse reactions: Omeprazole has fewer adverse reactions and is relatively safe for pregnant women, children and the elderly. Both are contraindicated in allergy to proton pump inhibitors, severe hepatic and renal insufficiency, infants and young children and pregnant and lactating women should be used with caution. It is recommended that patients choose drugs under the guidance of a physician and use them according to medical advice.