In pain clinics, many people have misconceptions about the concept of “closure” and feel fear and rejection. When these people hear about the need for injections, they will stare blankly, repeatedly and anxiously ask: “Doctor, is it a closure? Closed can not be played ah, closed the bones will be brittle, will be fat, etc.. There are many other ways to say it. There are also people who believe that the closure is a little anesthetic, anesthesia, once the effect of the drug, is not still painful? So what is closed, and what is the injection therapy it. Closure I have not found which formal textbook or academic book has a clear definition, my understanding is actually a pain injection. It is the injection of a mixture of local anesthetics, hormones, vitamins, circulation improvement and other drugs into the patient’s body lesion. Of course, this is mainly for diseases of the soft tissues of the body, including myofascia, muscle attachment points, ligaments, joint capsules, joint tendon sheaths, local scars, etc. Injectable treatments, on the other hand, include painful point injections, nerve blocks, and nerve disruption treatments. The connotation is much broader. A nerve block, as the name implies, is an injection of a drug to block a nerve. For example, cervical nerve root block, occipital nerve block, stellate ganglion block, thoracic paravertebral and lumbar paravertebral nerve root block, and epidural block are all commonly used. In the case of nerve destruction, nerve destruction drugs or radiofrequency destruction are used instead of local anesthetics. Will injections cause “brittle bones” and “fatness” as some people say? I don’t think so. This is because the hormones contained in the injections cause a lot of side effects. However, the amount of hormones contained in the injections is very small. The hormone contained in each injection, converted into prednisone, is only equivalent to 10 to 30 mg, and it is injected once a week or so apart. Physiologically, the physiological secretion of glucocorticoids in the human body then amounts to 5 to 10 mg per day. On this issue, Professor Ni Jiachao of the pain department of Xuanwu Hospital in Beijing did an experiment. The patient was given the equivalent of 20 mg of the hormone every other week, four times in a row, and the blood steroid concentration was monitored daily. The final result was that the concentration increased slightly during the treatment, and after 45 days, the steroid concentration in the body was completely normalized. There was no effect on the hypothalamic-pituitary-adrenocortical axis. It can be seen that there is no risk when the treatment is standardized in strict accordance with the course of treatment. In addition why does the nerve block work therapeutically, instead of still hurting once the anesthetic wears off? This mechanism is relatively complicated. 1, the block solution contains not only local anesthetics, but also anti-inflammatory drugs and so on. Many nerve pain, not necessarily the nerve itself produced lesions, but the nerve travel channel somewhere in the soft tissue inflammation, edema. Through nerve block, we not only block the nerve, but also eliminate the inflammation around the nerve, thus playing a role. For example, in occipital neuralgia, inflammation occurs in the area where the occipital nerve penetrates the posterior occipital fascia. While blocking the occipital nerve, we will also eliminate the inflammation of the soft tissues around the occipital nerve through anti-inflammatory drugs, thus restoring the normal function of the nerve. 2, peripheral nerves often contain sympathetic nerve components, we blocked the sensory nerve at the same time, but also blocked the sympathetic nerve, sympathetic nerve is widely distributed in the local capillaries and other places. Then the nerve block will make the soft tissue capillaries in the area of innervation dilate, improving the local blood circulation of the lesion, thus promoting the elimination of sterile inflammation. Of course there are many other mechanisms, what with the plasticity of nerve tissues and pain memory, not to mention them all. Today, with the aid of CT, C-arm, neurostimulator and other imaging and electronic technologies, injection therapy has developed from superficial site injections to deep site injections, such as trigeminal semilunar ganglion block, pterygopalatine ganglion block, thoracic sympathetic trunk block, ventral plexus block, lumbar sympathetic trunk block, lumbar epidural lateral saphenous fossa injection and so on. I sincerely hope that this medical treatment technology can be better developed in order to better serve the patients and the medical work of the hospital.