Bad moods and epilepsy are difficult bedfellows. The prevalence of epilepsy is significantly higher in people with depression and anxiety than in the general population, and in turn a very high proportion of people with epilepsy have symptoms of depression and anxiety. Patients with epilepsy are often associated with severe anxiety, neuroticism, hostility, and feelings of depersonalization, which can cause poor sleep quality, and reduced sleep can further precipitate seizures. In China, patients and physicians pay little attention to this aspect. Some medications, such as patients treated with phenobarbital are more likely to cause depression than patients treated with other medications and have significantly lower serum and red blood cell folate levels. Then there’s Tolterol, which is also more likely to cause depression. And certain antiepileptic drugs, such as sodium valproate and lamotrigine, can act as mood stabilizers and have some benefit for patients who are manic. It is important to pay attention to the mood of patients with epilepsy. For this reason, our recommended protocol is to routinely perform mood and personality assessments and, in patients with abnormalities, to give pharmacological interventions such as anti-anxiety and anti-depressant therapy, as well as transcranial magnetic stimulation to improve mood and sleep and suppress seizure discharges. Through comprehensive treatment, the life of epilepsy patients is made less gray and the quality of life is significantly improved.