Selective COX-2 inhibitors: prevention of gastrointestinal cancer and promotion of recovery from postoperative intestinal paralysis COX-2 inhibitors are effective analgesics and also have the ability to: 1. promote recovery from intestinal paralysis after gastrointestinal surgery; 2. prevent the occurrence of gastrointestinal tumors. Therefore, COX-2 inhibitors should be preferred for pain relief after gastrointestinal tumor (cancer) surgery. Of course, combined pain relief with opiates or continuous epidural pain relief can also be chosen. Preventive value of gastrointestinal cancers The use of nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the risk of esophageal, gastric, colon and other solid tumors. However, they can also lead to gastrointestinal side effects. Selective COX-2 inhibitors (cyclooxygenase-2 inhibitors, COX-2i), which have stronger anti-inflammatory effects and also have a lower chance of producing side effects such as ulcers, can reduce cancer cell proliferation, induce apoptosis, and inhibit the development of gastrointestinal tumors.