Playing ball knee pain may be due to excessive exercise, bursitis, rheumatoid arthritis, etc., according to the cause to take medication, surgical treatment. 1. Excessive exercise: If the knee pain is caused by too much playing time, usually no special treatment is needed, daily rest, moderate stretching, after a period of time will be relieved. 2. Bursitis: If bursitis causes knee pain from playing ball, patients can take oral non-steroidal anti-inflammatory drugs as prescribed by the doctor, such as ibuprofen, celecoxib and so on. Can also be local injection corticosteroid drug treatment such as prednisone acetate. If the drug treatment is not effective, the patient can also undergo bursaectomy treatment. 3. Rheumatoid arthritis: If rheumatoid arthritis caused by playing ball knee pain. Patients can take antibiotic medication as prescribed by the doctor, such as benzylpenicillin, amoxicillin and so on. If the pain symptoms are more serious, you can also take oral non-steroidal anti-inflammatory drug treatment, such as aspirin, indomethacin and so on. There are many reasons that lead to playing ball knee pain, it is recommended that patients seek medical attention in time to clarify the cause of the disease and standardized treatment.