Redness and swelling at the vaccination site on the second day after vaccination, if there is no other serious pain or discomfort, it is usually a normal phenomenon and does not require special treatment, it can be relieved on its own, or can be relieved by applying hot compresses. However, if the redness and swelling do not subside for a long time, and accompanied by hard knots, pain, ulceration and other symptoms, you can follow the doctor’s instructions through the topical medication, as well as oral or injectable drugs for treatment. 1. Hot compresses: 24 hours after vaccination can be appropriate local hot compresses to promote blood circulation at the vaccination site, to achieve the effect of swelling and pain, remember not to apply hot compresses within 24 hours of vaccination to avoid increased swelling, if there is pain, within 24 hours can be used to cold compresses to relieve pain. 2. Topical medication: magnesium sulfate solution can be applied externally as prescribed by the doctor, which can promote muscle relaxation and vasodilation to help relieve swelling and hardness. 3. Oral or injectable medication: If, in addition to redness and swelling, there are symptoms such as hardness, pain, ulceration, fever, etc., it may be caused by infection and allergy, and requires immediate medical attention. If it is caused by infection, oral antibiotic treatment, such as amoxicillin, can be prescribed. If allergy occurs, dexamethasone, loratadine, etc. can be used as prescribed by the doctor. The above drugs must be used under the guidance of a doctor, and should not be taken without authorization. In addition, after vaccination, pay attention to local cleanliness, so as not to aggravate the symptoms.