Small blisters on hands without itching or pain may be related to herpes sweat, post-friction blisters, palmoplantar pustulosis and other causes. 1. Sweat blisters: when sweating is not smooth, so that the sweat through the sweat ducts out of the skin is impeded, so that it appears in the subcutaneous stasis, which leads to the formation of small blisters, usually in the bilateral palms of the hands, the fingers side margins can be seen in the corn grain to soybean-sized blisters. Some patients may not have itching and pain. 2. Friction blisters: When the skin of the hands often rubbed, it may cause blisters on the hands, and there are no symptoms of discomfort in the early stage. 3. Palmoplantar pustulosis: this disease belongs to a type of psoriasis. Usually in the palm of the hand, on the basis of erythema, pinpoint-sized, unbreakable sterile pustules can be seen, with the characteristics of rising and falling, long lasting. There may be no itching or pain. When there are small blisters on the hands without itching and pain, you should avoid picking the blisters by yourself, so as not to cause local infection and aggravate the symptoms. If there are more blisters, it is recommended to go to the hospital, after clarifying the cause of the disease, to carry out symptomatic treatment.