Endometrioid adenocarcinoma is moderately differentiated and generally less malignant with a lower probability of bone metastasis. Endometrioid adenocarcinoma moderately differentiated simply indicates a pathological type of endometrial cancer, which can be early, intermediate, or advanced. The more differentiated the cancer cells are, the less malignant they are. Moderately differentiated endometrioid adenocarcinoma indicates an intermediate degree of malignancy and a lower likelihood of bone metastasis. Intermediate differentiation of endometrioid adenocarcinoma is generally of low malignancy, mostly confined to the endometrium, the basement of the uterus, and is more common in early stage patients. Whether bone metastasis occurs in moderately differentiated endometrioid adenocarcinoma needs to be analyzed and evaluated according to the extent of infiltration of moderately differentiated adenocarcinoma, clinical manifestations of patients and other factors. Patients with moderately differentiated endometrioid adenocarcinoma can listen to the doctor’s advice and adopt scientific and reasonable methods to actively treat the disease. Keep a good mindset, pay attention to regular diet and regular work and rest in daily life.