Pathologic cancer after surgery for colon cancer with no metastasis, no involvement of the vasculature, and visible nerve invasion is stage II. It is not very serious. Stage II colon cancer is divided into stage IIA, IIB and IIC according to the degree of invasion of the primary tumor (T), all of which have no lymph node metastasis and no distant metastasis.Stage IIA refers to the tumor penetrating the intrinsic muscular layer to reach the colorectal parietal tissues, Stage IIB refers to the tumor penetrating the visceral peritoneum, and Stage IIC refers to the tumor directly invading or adhering to the neighboring organs or structures. Stage II colon cancer with nerve invasion belongs to stage II colon cancer patients with high risk factors, and postoperative adjuvant chemotherapy is needed after surgery. Colon cancer patients should receive standardized treatment under the guidance of oncologists after surgery.