Magnesium sulfate with contraindicated drugs are polymyxin B sulfate, streptomycin sulfate, calcium gluconate, dobutamine hydrochloride, procaine hydrochloride, tetracycline, penicillin, nafcillin that is ethylene oxynaphthalene penicillin, vitamin K1. guide diarrhea, such as taking a large number of solutions with too high a concentration, may absorb a large amount of water in their own tissues and lead to dehydration. Gastrointestinal tract with ulcers, broken places, easy to cause a large amount of magnesium ion absorption and cause poisoning. Intestinal bleeding patients, patients with acute abdomen, as well as pregnant women, menstruating women are prohibited to induce diarrhea with this product. There is a certain danger when intravenous drip, it must be carried out slowly and 10% calcium gluconate injection should be prepared for relief. In the event of poisoning, slow intravenous injection of calcium chloride or calcium gluconate should be given immediately for emergency resuscitation. The injection dosage should be reduced in renal insufficiency, and should be prohibited in anuric patients because it can lead to magnesium ion accumulation poisoning.