A few days ago, our department admitted a patient with malignant transformation to squamous carcinoma due to penetrating folliculitis of the buttocks. The patient’s buttocks had been repeatedly ulcerated for 40 years, locally malignant, forming a tumor of about 25cm×20cm, and the pathological result was squamous cell carcinoma, with the tumor invading around the anus. After careful discussion and careful surgical plan in our department, the patient’s trauma was well repaired after four hours of surgery and comprehensive postoperative care. Excavatory folliculitis is one of the manifestations of the follicular atresia triad. The follicular atresia triad refers to the presence of three separate disorders, polymerized acne, suppurative sweating and periungual perforating folliculitis, in the same patient. It is a relatively rare, autosomal dominantly inherited skin disorder that is prevalent in young males. It is a rare chronic suppurative skin disease that runs in families. When the abscess penetrates deep into the subcutaneous tissue, a draining sinus tract covered with epidermis is formed, and extensive fibrosis is seen in the healing area. Suffer from exhumation folliculitis is painful, due to repeated folliculitis and perifolliculitis, inflammation to the deeper development of hemispherical nodules, nodules soften and form pustules, ruptured into most fistulas; due to deep subcutaneous tissue erosion and destruction of the formation of sinus tracts, interconnected, repeated flow of pus. To bring unchanged life, the most terrible long-term repeated skin ulcers, leading to malignant changes, life-threatening. Suffer from excavated folliculitis, daily life should pay attention to: local should be sterilized, anti-inflammatory, dry as the principle to deal with. On weekdays in the diet should also eat less alcohol, as well as, sour and spicy and other stimulating food. Eat more vegetables and fruits. Pay attention to the cleanliness of the skin in your daily life. Unfortunately, it is difficult to cure at present, treatment, oral retinoic acid, inhibit follicular keratinization, reduce follicular atresia, inhibit sebum secretion, as well as local anti-inflammatory effect; acute inflammatory period of the application of antibiotics is effective in reducing purulent secretion discharge and relieving pain; early inflammatory reaction is obvious, the application of a small dose of glucocorticoids can help the inflammation to subside and stop the destruction of tissues. Surgery can be performed to incise and drain the abscess, as well as plasticizing the healing scar. In case of recurrent suppurative infections, we recommend early radical surgery in our department, which improves the quality of life and avoids malignant changes. One of the recently admitted patients lost the best time for surgery and the chance of radical treatment because of the invasion of the iliac bone and other parts of the body.