Cirrhosis generalized weakness unable to walk and difficulty in speaking is considered to be related to gastrointestinal bleeding, blood volume insufficiency, hypokalemia, hepatic encephalopathy, etc.. Gastrointestinal bleeding should be treated with rehydration, blood transfusion, acid suppression and endoscopic surgery if necessary; hypokalemia should be treated with potassium supplementation; hepatic encephalopathy should be treated with lactulose enema and L-ornithine and L-mentholine. 1. General treatment: pay attention to bed rest, diet should be given to high vitamin, easy to digest food, strictly prohibit alcohol, eat more vegetables and fruits, avoid eating hard and rough food, bleeding should be fasting. 2. Gastrointestinal bleeding: cirrhosis, generalized weakness, can’t walk, difficult to talk, should be observed with or without gastrointestinal bleeding, bleeding volume of blood volume is insufficient can have generalized weakness, should be fasting water, rehydration, blood transfusion, omeprazole, etc. to inhibit the secretion of gastric acid, if necessary, endoscopic hemostasis. 3. Hypokalemia: Cirrhosis of the whole body weakness can not walk and talk difficult to consider whether there is hypokalemia, hypokalemia is often muscle weakness, should be given to potassium treatment, combined with ascites can be applied to spironolactone, not only diuretic but also promote potassium. 4. Hepatic encephalopathy: Cirrhosis combined with hepatic encephalopathy can have neuropsychiatric symptoms, there can be generalized weakness, can not walk and talk difficulties, should be prohibited or restricted protein intake, lactulose enema acidification of the intestinal tract to reduce the absorption of ammonia, L-Ornithine L-Menthionine to reduce blood ammonia. Liver cirrhosis generalized weakness can not walk and talk difficulty should go to the hospital, under the guidance of the doctor’s treatment.