Patients are easily irritated by small things because they are irritable. A general stimulus can cause a strong, negative and unpleasant emotional experience, which is irritable. When patients encounter minor frustrations, they become agitated, angry, or even irritable, which is the case of irritable people. It is commonly seen clinically in manic states, mental disorders due to brain and somatic diseases, and in patients with neurological disorders. Adolescent children with depression can also be irritable, easily getting angry, raging, or even showing aggressive behavior because of the slightest thing. For different disorders, a systematic and standardized examination should be performed to confirm the diagnosis in relation to the clinical reality. For example, if a patient with depression has symptoms such as depressed mood, slowed thinking, and reduced volitional activity, the patient needs to be examined to confirm whether he or she has depression. Once the diagnosis is confirmed, systematic and standardized antidepressant treatment is needed to achieve good treatment results.