Clopidogrel and aspirin have different mechanisms of action and can be used for antiplatelet therapy. Clopidogrel and aspirin are both antiplatelet drugs, clinically used in ischemic cardiovascular and cerebrovascular diseases, clopidogrel’s main role is to inhibit ADP receptors, inhibit platelet aggregation, while aspirin mainly inhibit the activity of cyclooxygenase, resulting in the body of the reduction of thromboxane a2 generation, thereby inhibiting the function of platelets, the two drugs through different mechanisms to inhibit the aggregation of platelets. The adverse reactions of clopidogrel are stomach pain, gastric distension, abdominal pain, diarrhea, skin and mucous membrane bleeding, cerebral hemorrhage, etc. It is forbidden for patients who are allergic to the drug components, severe hepatic impairment, and active bleeding. Adverse reactions to aspirin include stomach upset, nausea, vomiting, skin mucous membrane bleeding, gastrointestinal bleeding, urinary tract bleeding, etc. It is contraindicated in patients with allergy to drug components, severe hepatic impairment, aspirin-related asthma, hemophilia, and active ulcers. The drug is recommended to be used under the guidance of a doctor to avoid blindly using the drug on your own.