Acne marks are scarring or pigmentation left behind after acne subsides, there is no such thing as which medication is effective, and individualized treatment needs to be given for the patient’s specific situation in order to achieve a good therapeutic effect. For post-inflammatory hyperpigmentation can be externally applied hydroquinone cream, retinoic acid cream, cumquat cream ointment and other drugs; for scarring patients can use silicone preparations, compound heparin sodium allantoin gel and other drugs for treatment. For the post-inflammatory hyperpigmentation left behind by acne, patients can use hydroquinone cream, vinpocetine cream, cumulonimbus cream ointment and other drugs for local application under the guidance of the doctor, such drugs can lighten the hyperpigmentation, promote the normal keratinization of the skin surface, inhibit the proliferation of collagen fibers, and improve and lighten the role of post-inflammatory hyperpigmentation. For patients with acne scarring, silicone preparations, such as silicone gel ointment and silicone gel patch, can be used under the guidance of doctors; drugs such as compound heparin sodium allantoin gel can also be used for treatment. The above medications are also effective in treating hyperplastic scarring and keloids. Usually, the effect of topical medication for acne marks is limited, and patients are advised to follow the doctor’s instructions for combined phototherapy and so on. In life, patients should also pay attention to personal hygiene, keep the facial skin clean and dry, do a good job of sun protection, avoid scratching acne marks, so as not to cause infection.