Non-calcified plaque with severe stenosis can be treated by lifestyle modification, medication, or surgery. 1. Life management: patients should pay attention to a light and easy-to-digest diet, low-fat and low-salt diet, regular life, ensure sufficient sleep, and appropriate physical exercise, avoiding various triggers of atherosclerosis, which is of positive significance to the treatment of non-calcified plaque. 2. Drug treatment: patients can take aspirin enteric-coated tablets, clopidogrel bisulfate tablets, atorvastatin calcium tablets or Rosuvastatin calcium tablets under the guidance of doctors, which can also effectively improve the treatment of non-calcified plaques with severe stenosis, but it may need to be taken for the rest of one’s life. The specific medication should be prescribed by the doctor. 3. Surgery: If the severe stenosis of non-calcified plaque is more serious, on the basis of standardized drug treatment, it can be treated by intracoronary stent implantation surgery, which can also achieve a better therapeutic effect. After diagnosis of severe non-calcified plaque stenosis, patients should actively cooperate with the treatment, according to the doctor’s guidance and individual circumstances to carry out targeted treatment, to avoid delaying the condition leading to further deterioration of the symptoms aggravated.