Clinically, increased neutrophils are often accompanied by increased leukocytes. Increased leukocytes, increased neutrophils, and decreased lymphocytes are most often seen during acute infections and severe tissue injuries, such as severe trauma such as fractures, or after gastrointestinal surgery, gynecological surgery, or extensive burns, which can cause high leukocytes, high neutrophils, and low lymphocytes. In addition, leukocyte and neutrophil counts may increase in the presence of hemorrhage and intravascular hemolysis. Metabolic disorders in the body, such as metabolic acidosis and chemical toxicity, can also increase leukocytes and neutrophils, and chronic granulocytic leukemia and advanced malignant neoplasms can also cause high leukocytes, high neutrophils, and low lymphocytes. Therefore, high leukocytes, high neutrophils, and low lymphocytes may be due to a variety of causes, which should be clinically analyzed and differentiated on a case-by-case basis.