Uncomfortable throat may be dry and lack of water, chronic hypertrophic pharyngitis, acute simple pharyngitis, reflux pharyngitis, laryngeal cancer and other reasons. 1. Dryness and dehydration: physiological factors such as drinking too little water, breathing with mouth open for a long time, high ambient temperature, poor air circulation, and staying up late for a long time lead to dryness and dehydration of the mucous membrane of the throat, which makes the throat uncomfortable. 2. Chronic hypertrophic pharyngitis: Repeated bacterial infections and other factors lead to chronic hypertrophic pharyngitis, extensive connective tissue and lymphoid follicle hyperplasia under the pharyngeal mucosa, mucosal hypertrophy and congestion, secretion increases, so it will be uncomfortable throat. 3. Acute simple pharyngitis: viral invasion of the upper respiratory tract leads to acute inflammatory reaction of the mucous membrane of the throat, a large number of inflammatory substances exudate leading to pharyngeal congestion, edema, so the throat will be uncomfortable. 4. Reflux laryngitis: gastric acid and other gastric substances reflux to the pharynx, corrode and stimulate the mucous membrane of the pharynx, leading to uncomfortable throat. 5. Laryngeal cancer: malignant hyperplasia of laryngeal tissues leads to local occupation, and the cancerous tissues in the middle and late stages cause serious damage to the surrounding normal tissues, which will lead to uncomfortable voice. For serious cases, it is recommended to consult doctors to clarify the cause of the disease and carry out targeted treatment.