Kidney cancer grade 1 can be any stage in kidney cancer staging. Kidney cancer grading is differentiated by the pathology of clear cell carcinoma and papillary renal cell carcinoma. Kidney cancer staging is based on the size, location, and the presence or absence of metastasis of the tumor. 1. Renal cancer grading: it is divided into 4 grades through the pathology of clear cell carcinoma and papillary renal cell carcinoma: (1) Grade 1: 400× microscopic nuclei are absent or inconspicuous and basophilic. (2) Grade 2: nucleoli are obvious and eosinophilic under 400× microscopy, visible but not prominent under 100× microscopy. (3) Grade 3: nucleoli are clearly visible and eosinophilic at 100×. (4) Grade 4: obvious nuclear pleomorphism, multinucleated tumor giant cells and/or rhabdomyosarcoma-like and/or sarcoma-like differentiation can be seen. 2. Kidney cancer staging: according to the size, location and metastasis of the tumor, it is divided into 4 stages (T stage): (1) Stage 1 renal cancer: the tumor is less than 7 cm and confined within the kidney. (2) Stage 2 renal cancer: the tumor is larger than 7 cm, the tumor is still confined within the kidney, no lymphatic metastasis has occurred, and there is no invasion outside the kidney. (3) Stage 3 renal cancer: the tumor invades the renal veins, peri-renal tissues, there are cancer clots in the veins and lymph node metastasis. (4) Stage 4 renal cancer: the tumor invades and exceeds the perinephric fascia, invades some organs including those around the kidneys, liver, intestines, pancreas, and even occurs lymphatic distant metastasis in the chest and neck. Generally, stages 1 and 2 are categorized as early stage, stage 3 is progressive stage, and stage 4 belongs to advanced stage of kidney cancer. Therefore, patients with grade 1 kidney cancer may be in early, progressive or advanced stage, and patients should actively cooperate with doctors’ treatment.