Late night stomach pain is a clinical symptom caused by various pathogenic factors that lead to different degrees of damage to the gastric mucosa and increased sensitivity of the stomach nerves, often considered to be related to gastrointestinal colds, gastrointestinal dysfunction, gastritis, duodenal ulcer. 1. Gastrointestinal cold: If the patient has cold symptoms such as nasal congestion and runny nose during the onset of the disease, as well as indigestion such as diarrhea, nausea, vomiting, abdominal distention and loss of appetite, the possibility of having a gastrointestinal cold is considered greater. This condition is mainly related to the combination of coxsackie virus infection during the cold. Since viral infection is self-healing, so in clinical treatment, it is recommended to take cold medicine such as aminogalactam capsule to actively treat the cold, while using multi-enzyme tablets, lactobacillin tablets and other drugs to relieve gastrointestinal discomfort symptoms; 2, gastrointestinal dysfunction: if patients recently eat irregular diet, or often eat irritating, indigestible food, easy to increase the digestive burden of the gastrointestinal tract, resulting in the gastrointestinal tract internal environment The symptoms of late-night stomach pain may be caused by disturbances in the gastrointestinal tract, and may be accompanied by a decrease in appetite, bloating, diarrhea, constipation and other indigestion. It is recommended to take pepsin tablets and other digestive drugs as prescribed by the doctor, and pay attention to a light diet, avoiding spicy and stimulating foods for the time being; 3. gastritis: during the onset, patients are prone to recurrent clinical symptoms such as acid reflux, heartburn, irregular stomach pain, bloating and nausea. When factors such as irregular rest, alcohol consumption or improper diet lead to aggravation of gastritis, it can trigger late-night stomach pain symptoms. If you are diagnosed with gastritis, you need to take bismuth citrate ranitidine tablets, omeprazole enteric soluble tablets, etc., with colloidal bismuth capsules and other gastric mucosal repair agent treatment; 4, duodenal ulcer: for patients who are prone to recurrent late-night stomach pain, or stomach pain symptoms are obvious when hungry or emotional, consider the possibility of having duodenal ulcer. Late night stomach pain is mostly considered to be related to acidic gastric contents discharged into the duodenum, stimulating the duodenal ulcer surface. For treatment, it is recommended to choose rabeprazole sodium enteric dissolved tablets, amoxicillin capsules, clarithromycin capsules, rehabilitation new liquid, etc. under the guidance of a doctor. Also pay attention to regular diet and keep sufficient rest time.