All factors that cause permanent damage to kidney function can cause uremia. The first one is immunodeficiency, the most common one is chronic nephritis, immune, glomerular or vascular, and another one is lupus erythematosus nephritis, allergic purpura nephritis, mainly because there is a defect in immunity when you were born. Secondly, there are some clear congenital diseases, such as congenital polycystic kidney, and vascular diseases that cause problems in the vascular supply of the kidney. The third one is metabolic diseases, such as severe diabetes, severe hypertension causing kidney function damage. The fourth one is drug poisoning in daily life, some drugs can cause permanent damage to kidney function when taken for a long time or in large doses. There is another kind of accident in life, such as pyrexia and crush syndrome, which can also cause permanent damage to kidney function and cause uremia.